Evaluation of HIF1A Expression Level and Parenchymal-Stromal Relationships after Traumatic Air Shock Wave Exposure to the Liver

The purpose of the study was to investigate, analyze and evaluate expression level HIF1A parenchymal-stromal relations after traumatic air shock wave exposure liver. Materials methods. material for liver 30 male rats, weighing 177.5 ± 15.8 g. All animals were randomly divided into three groups: group 1 consisted intact rats (n - 6), 2 – control (halothane anesthesia with fixation) 12), 3 12) experimental fixation, single action an excess pressure 31.6 4.8, which generated in device developed by us). In order reactive changes wave, immunohistochemical method used hypoxia marker a morphometric analysis on 7th 30th day experiment. Results discussion. studied transcription factor showed relationship consequences that occur injury (alteration, inflammation, regeneration), as well observation period distribution parenchyma. Despite diffuse liver, occurs low-intensity we record high threshold resistance cells this factor. absence one month is direct indication restoration functioning specialized cells, despite initial significant at microcirculatory channel lobules. Research has repeatedly shown regenerative potential factors influence, toxic, mechanical, others. Understanding spatial response external internal will allow us assess adaptive capabilities metabolism hepatocytes are different conditions blood supply, expand our knowledge about pathogenesis post-traumatic offer new therapeutic tools their correction. Conclusion. Morphometric decrease area 8% increase connective tissue almost 2.4 times comparison animals. Evaluation stages moderate characteristic subcapsular early period. On period, accumulation not statistically compared